2010 NBTS MEETING - PRELIMINARY PROGRAM
Thirty-fourth Annual Meeting of the Neurobehavioral Teratology Society
Held in Conjunction with the 50th Annual Meeting of the Teratology Society and the 22nd Annual Meeting of the Organization of Teratology Information Specialists
Louisville, KY June 26 - June 30, 2010
Saturday, June 26, 2010
8:00 a.m.-11:30 a.m. Teratology Society Education Course*: Marriott
Ballroom 6
12:30 a.m.-5:30 p.m. Teratology Society/OTIS Pregnancy Workshop*: Marriott Ballroom 9
1:30 p.m.-4:45 p.m. Teratology Society Education Course*: Marriott Ballroom 6
*Separate Registration
1:00 p.m.-5:00 p.m. NBTS Registration: Marriott Ballroom 7 Foyer
1:00 p.m.-2:00 p.m. NBTS Public Affairs Committee: Filly Meeting Room
2:00 p.m.-3:00 p.m. NBTS Publications Committee Meeting: Filly Meeting Room
3:00 p.m.-6:00 p.m. NBTS Council Meeting: Filly Meeting Room
Sunday, June 27, 2010
8:00 a.m.-5:00 p.m. NBTS Registration: Marriott Ballroom 7 Foyer
7:45 a.m.-8:15 a.m. Continental Breakfast: Marriott Ballroom 7
8:15 a.m.-8:30 a.m. President's Welcome and Official Opening of 2010 NBTS Meeting
Marriott Ballroom 7
8:30 a.m.-12:00 a.m. Session 1, Behavioral Toxicology Symposium,
Behavioral Toxicology of Cognition: Extrapolation from Experimental Animal Models to Humans
Chairperson: Merle Paule, National Center for Toxicological Research
Marriott Ballroom 7
8:30-8:50 Introduction
Merle Paule
National Center for Toxicological Research, Jefferson, AR
8:50-9:25 Delay Discounting by Humans and Other Animals: Does the Species Matter?
Leonard Green
Washington University, St. Louis, MO
9:25-10:00 The Use of "Animal" Tests of Cognition in Children
William H. Overman
University of North Carolina, Wilmington, NC
10:00-10:15 Break
10:15-10:50 Modeling the Cognitive Deficits of Parkinson's Disease
Jay Schneider
Thomas Jefferson University, Philadelphia, PA
10:50-11:25 Delineating Behavioral Domains Underlying Lead-Induced Cognitive Deficits
Deborah Cory-Slechta
University of Rochester Medical School, Rochester, NY
11:25-12:00 Perinatal PCB Exposure and Deficits In Inhibitory Control: Parallels Between Animals And Humans
Susan Schantz
University of Illinois, Urbana IL
12:00 p.m.-1:20 p.m. Lunch on your own
1:20 p.m.-3:00 p.m. Session 2, NBTS Platform Talks: Marriott Ballroom 7
Chairperson: Phillip Bushnell, US-Environmental Protection Agency
1:20 p.m.-1:40 p.m. The Effect of 2,4-Dichlorophenoxyacetic Acid on Anxiety in the Rat.
William Hamlet, Sandra McFadden, Russell Morgan, Amy Vaught
Western Illinois University, Macomb, IL
1:40 p.m.-2:00 p.m. Prenatal Exposure to Phthalates and Newborn Neurobehavior
Kimberly Yolton, Yingying Xu, Jane Khoury
Cincinnati Children's Hospital, Cincinnati, OH
2:00 p.m.-2:20 p.m. Early Developmental Chlorpyrifos Causes Persisting Behavioral and Neurochemical Changes in Zebrafish
Damiyon Sledge, Ann Petro, Jerry Yen, Susan Donerly, Elwood Linney, Edward Levin
Duke University Medical Center, Durham, NC
2:20 p.m.-2:40 p.m. Reversal of Chlorpyrifos Neurobehavioral Teratogenicity in Mice by Adult Allographic Subventricular Zone-derived Neural Stem Cell Transplantation
Joseph Yanai1 ,2, Adi Pinkas1
1The Ross Lab for Studies in Neural Birth Defects, Department of Medical Neurobiology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel, 2Department of Pharmacology and Cancer Biology, Duke Medical School, Durham, NC
2:40 p.m.-3:00 p.m. The Long-term Behavioral Effects of Exposure to Metals and Chronic Stress during Development
Devon Graham1 ,2, Robyn Amos-Kroohs1 ,2, Amanda Braun1 ,2, Curtis Grace1 ,2, Tori Schaefer1 ,2, Matthew Skelton1 ,2, Charles Vorhees1 ,2, Michael Williams1 ,2
1Cincinnati Children's Research Foundation, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH
3:00 p.m.-3:20 p.m. Break: Marriott Ballroom 7 Foyer
3:20 p.m.-5:00 p.m. Session 3, NBTS Platform Talks: Marriott Ballroom 7
Chairperson: Lori Driscoll, Colorado College
3:20 p.m.-3:40 p.m. Effects of 3,4-Methylenedioxymethamphetamine (MDMA) on Serotonin Transporter and Vesicular Monoamine Transporter 2 Protein and Gene Expression in Rats: Implications for MDMA Neurotoxicity
Dominik Biezonski1 ,2, Jerrold Meyer1
1University of Massachusetts, Amherst, MA, 2Harvard Medical School, Southborough, MA
3:40 p.m.-4:00 p.m. Effects of Prenatal Cocaine on Conditioned Place Preference in Adolescence: Modification by Post-weaning Housing and Sex
Diana Dow-Edwards1, Sari Izenwasser1
1State University of New York, Brooklyn, NY, 2University of Miami School of Medicine, Miami, FL
4:00 p.m.-4:20 p.m. Evidence for Rapid Sensitization to the Stimulant Effects of MDMA in Adolescent Rats
Jerrold Meyer, Peter Kim, Frederico Fernandes, Dominik Biezonski, Brian Piper
University of Massachusetts, Amherst, MA
4:20 p.m.-4:40 p.m. Methylphenidate-Induced Developmental Neurobehavioral Toxicity in Zebrafish
Edward Levin, Damiyon Sledge, Stephanie Roach, Susan Donerly, Elwood Linney
Duke University, Durham, NC
4:40 p.m.-5:00 p.m. Effects of Overlapping Ages of Exposure to (+)-Methamphetamine (MA) in Rats on Later Allocentric and Egocentric Learning
Charles Vorhees, Matthew Skelton, Devon Graham, Tori Schaefer, Curtis Grace, Amanda Braun, Robyn Amos-Kroohs, Michael Williams
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
6:00 p.m.-8:00 p.m. Joint NBTS/TS/OTIS Welcome Reception: Marriott Ballroom 1
Monday, June 28, 2010
8:00 a.m.-5:00 p.m. NBTS Registration: Marriott Ballroom 7 Foyer
7:45 a.m.-8:15 a.m. Continental Breakfast: Marriott Ballroom 7
8:15 a.m.-9:00 a.m. Session 4, Elsevier Distinguished Lectureship
Bisphenol-A Impacts on Sex Differences in Neural Processes
Neil MacLusky, University of Guelph, ON
Marriott Ballroom 7
9:15 a.m.-11:45 a.m. Session 5, Reproductive Psychiatry Symposium (NBTS/OTIS/TS)
Chairpersons: Katherine L. Wisner, University of Pittsburgh Medical Center and Adrienne Einarson , The Motherisk Program
Marriott Ballroom 6
9:15 a.m.-9:20 a.m. Introduction
9:20 a.m.-9:50 a.m. Where Does Neonatal Behavioral Syndrome End and Neurobehavioral Teratogenicity Begin?
Tim F. Oberlander, University of British Columbia, Vancouver, BC
9:50 a.m.-10:20 a.m. Messages from the Womb: Maternal Antidepressant Use and Fetal Neurobehavior
Amy L. Salisbury, Alpert Medical School of Brown University, Providence, RI
10:20 a.m.-10:50 a.m. An Update on Lithium Treatment during Pregnancy and Lactation
Adele C. Viguera, Neurological Institute, Cleveland Clinic, Cleveland, OH
10:50 a.m.-11:20 a.m. Effects of Developmental Exposure to Methylphenidate on Brain Areas Involved in Cognition, Motivated Behaviors, Appetite and Stress
Teresa Ann Milner, Weill Cornell Medical College, New York City, NY
11:20 a.m.-11:45 a.m. Discussion: How Do We Incorporate These Data into Human Risk Assessment?
Katherine L. Wisner, University of Pittsburgh Medical Center, Pittsburgh, PA
12:00 p.m.-1:15 p.m. Lunch on your own
1:15 p.m.-4:45 p.m. Session 6, Symposium
Complementary Zebrafish Models for Neurobehavioral Teratology Research: Opportunities and Challenges
Chairperson: Edward D. Levin, Duke University Medical Center
Marriott Ballroom 7
1:15 p.m.-1:45 p.m. Embryonic Exposure to Low Levels of Alcohol: Towards the Development of a Realistic Zebrafish Model of Fetal Alcohol Syndrome
Robert Gerlai, University of Toronto, Toronto, ON
1:45-2:15 Ethanol-induced Effects on Neurobehavioral Function: the Developmental Neurotoxicity of MicroRNAs
Tamara Tal, Katerine Saili, Jill Franzosa, Robert Tanguay
Oregon State University, Corvallis, OR
2:15 p.m.-2:45 p.m. Do NMDA Receptor Antagonists Alter Structural and Functional Development in Zebrafish?
Frank Scalzo
Bard College, Annandale-on-Hudson, NY
2:45 p.m.-3:00 p.m. Break: Marriott Ballroom 7 Foyer
3:00 p.m.-3:30 p.m. Evaluating the Behavioral Impact of Toxicants in Larval Zebrafish
Robert MacPhail
US Environmental Protection Agency, Research Triangle Park, NC
3:30 p.m.-4:00 p.m. Using the Zebrafish (Danio rerio) Model to Investigate Changes in Gene Expression and Behavior following Developmental Exposure to Pyrethroid Pesticides
Lori White1, Keith Cooper1, Amy DeMicco1, Jason Richardson2
1Rutgers, The State University of NJ, New Brunswick, NJ, 2Environmental and Occupational Health Sciences Institute, UMDNJ, Piscataway, NJ
4:00 p.m.-4:30 p.m. Using Zebrafish to Investigate Persisting Cognitive and Sensorimotor Effects of Early Developmental Chlorpyrifos Exposure
Edward D. Levin
Duke University Medical Center, Durham, NC
4:30-4:45 Discussion
5:00 p.m.-7:00 p.m. Joint Poster Session I (NBTS/TS/OTIS) and Exhibits Open (Posters set up at 11:45 a.m., attended 5:00 - 7:00 p.m.)
Marriott Ballroom 1
Neurobehavioral Development following Exposure of Male Mice to Polybrominated Diphenyl Ether 47 on Postnatal Day 10
Virginia Moser1, Pamela Phillips1, Katherine McDaniel1, Jill Gee1 ,2
1US Environmental Protection Agency, Research Triangle Park, NC, 2North Carolina State University, Raleigh, NC
Subsequent Effects on Open-field Responses of Exposing Male and Female Hooded Rats Each Day to Alcohol, Caffeine and their Combination during Early and Mid to Late Adolescence, and Early Adulthood.
Rob Hughes
University of Canterbury, Christchurch, New Zealand
Gene Expression in Developing Brain is Altered by Modest Reductions in Circulating Levels of Thyroid Hormone.
Mary Gilbert, Kevin Crofton, Gail Nelson, Geremy Knapp
US Environmental Protection Agency, Research Triangle Park, NC
Molecular (Mal)adaptations in Dopamine-modulated Signaling Pathways following Neurodevelopmental Insult
Aliya Frederick, Roger Colbran, Gregg Stanwood
4Vanderbilt University, Nashville, TN
Effects of Methylphenidate on Motivation in Children with Attention-Deficit/Hyperactivity Disorder
John Chelonis1 ,2, Teresa Johnson2, Sherry Ferguson1 ,2, Brian Kubacak2, Mark Edwards2, Merle Paule1 ,2
1National Center for Toxicological Research, FDA, Jefferson, AR, 2University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, AR
Effect of Lifetime Exposure to Acrylamide on Motor Nerve Conduction Velocity in Rats at One Year of Age
Joan Garey1, Zbigniew Binienda2, Merle Paule2
1SRC, Inc, Arlington, VA, 2 National Center for Toxicological Research, FDA, Jefferson, AR
Tuesday, June 29, 2010
8:00 a.m.-5:00 p.m. NBTS Registration: Marriott Ballroom 7 Foyer
7:45 a.m.-8:15 a.m. Continental Breakfast: Marriott Ballroom 7
8:30 a.m.-9:15 a.m. Special Lecture (NBTS/TS/OTIS)
Children's Environmental Health: A Good Start Lasts a Lifetime
Linda S. Birnbaum, National Institute of Environmental Health Sciences
Marriott Ballroom 6
9:30 a.m.-12:00 p.m. Session 7, Symposium (NBTS/TS)
Advancing Neurodevelopmental Evaluation in Children:
An Interdisciplinary Approach
Chairperson: Susan Makris, US Environmental Protection Agency
Marriott Ballroom 6
9:30 a.m.-9:55 a.m. The Use of Neurodevelopmental Data in Children for Risk Assessment of Environmental Chemicals
Susan Makris, US Environmental Protection Agency, Washington, DC
9:55 a.m.-10:20 a.m. A Multidisciplinary Approach to Advancing the Science of Neurodevelopmental Testing in Cohorts of Infants and Young Children
Judy S. LaKind, LaKind Associates, LLC, Baltimore, MD
10:20 a.m.-10:45 a.m. How to Get the Biggest Bang for Your Buck: Choosing Neurodevelopmental Tests that Maximize Power
Lauren Kenworthy, George Washington University Medical School, Washington, DC
10:45 a.m.-11:10 a.m. Threats to Study Validity: The Flynn Effect, Examiner Drift, Confounders, Lost in Translation, and Other Important Considerations
Laura Gutermuth Anthony, George Washington University School of Medicine, Washington, DC
11:10 a.m.-11:35 a.m. Weight-of-the-Evidence Assessment in Neurodevelopmental Epidemiology: A Plea for Consistency
Michael Goodman, Emory University, Atlanta, GA
11:35 a.m.-12:00 p.m. Panel Discussion
12:00 p.m.-2:00 p.m. NBTS/TS Joint Lunchtime Poster Session II and Exhibits Open (Posters set up at 11:45 a.m., attended 12:00 - 2:00 p.m.)
Marriott Ballroom 1
Effects of Domoic Acid on Early Visual Memory in Infants from the CoASTAL Cohort
Kimberly Grant1, Tom Burbacher1, Sparkle Roberts2, Lynn Grattan2
1University of Washington, Seattle, WA, 2University of Maryland, Baltimore, MD
Acute Postnatal Exposure to the PentaBDE Commercial Mixture DE-71 at Low Doses (5 or 15 mg/kg/day) Does Not Produce Learning or Attention Deficits in Rats
Lori Driscoll
Colorado College, Colorado Springs, CO
Gene-toxicant Interactions: Developmental PBDE Effects on the Behavioral Phenotype of the Mecp2-308 Rett Syndrome Mouse Model
Mari Golub, Roxanne Vallero, Joanne Suarez, Ta Tram Anh, Isaac Pessah, Robert Berman, Janine LaSalle
University of California Davis, Davis, CA
Locomotor Responding in Adolescent CD-1 Mice following Acute and Chronic Cocaine Administration is Unaffected by Low Dose Perinatal Bisphenol A Exposure
Jenna Nelms, Abby Meyer, Mellessa Miller, Melissa Ward, Helen Sable
University of Memphis, Memphis, TN
Developmental Neurobehavioral Toxicity of Bisphenol A: Defining the Role of Estrogen Related Receptor Gamma
Katerine Saili, Jane LaDu, Michael Simonich, Robert Tanguay
Oregon State University, Corvallis, OR
2:00 p.m.-3:40 p.m. Session 8, NBTS Platform Talks: Marriott Ballroom 7
Chairperson: Diana Dow-Edwards, Downstate Medical Center, Brooklyn, NY
2:00 p.m.-2:20 p.m. Genetic Susceptibility to PCB-induced Motor Dysfunction
Chris Curran, Emily Altenhofen, Amber Evans, Rikki Floyd, Cellestine Kamau-Cheggeh, Sarah Kraemer, Breann Hays, Kristi Haik
Northern Kentucky University, Highland Heights, KY
2:20 p.m.-2:40 p.m. Assessment of Prefrontal Cortical Functions in Mice with Genetic and Dietary Alterations of Folate Status
Jessica Ash, Barbara Strupp
Cornell University, Ithaca, NY
2:40 p.m. -3:00 p.m. Behavioral Outcome in Children Exposed Prenatally to Lamotrigine, Valproate, or Carbamazepine: Increased Risks for Valproate
Uma Deshmukh1, Jane Adams2, Ruby Dhillon1, Katherine McCarthy1, Eric Macklin1, Lewis Holmes1 ,3
1Massachusetts General Hospital, Boston, MA, 2University of Massachusetts Boston, Boston, MA, 3Harvard Medical School, Boston, MA
3:00 p.m.-3:20 p.m. Effects of Age of Exposure to 3,4-Methylenedioxymethamphetamine (MDMA) in Rats on Later Learning and Behavior
Charles Vorhees, Matthew Skelton, Devon Graham, Tori Schaefer, Curtis Grace, Amanda Braun, Michael Williams
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
3:20 p.m.-3:40 p.m. Predicting the Acute Behavioral Effects in Rats Inhaling Toluene for Up to 24 hrs: Inhaled vs. Internal Dose Metrics and Tolerance.
WM Oshiro, QT Krantz, CJ Gordon, EM Kenyon, and PJ Bushnell
US Environmental Protection Agency, Office of Research and Development, National Health Effects and Environmental Research Laboratory, Research Triangle Park, NC
3:40-4:00 Break: Marriott Ballroom 7 Foyer
4:00 p.m.-5:30 p.m. Annual NBTS Business Meeting: Marriott Ballroom 7
6:00 p.m.-9:00 p.m. NBTS Social Event, Riverboat Cruse
Wednesday, June 30, 2010
7:30 a.m.-9:00 a.m. Continental Breakfast: Marriott Ballroom 7
9:00 a.m.-10:45 a.m. Session 9, Future Directions in Neurobehavioral Teratology Roundtable
Discussants: Philip Landrigan, Jerrold Meyer, Susan Schantz, Lynn Singer, Charles Vorhees,
Marriott Ballroom 7
10:45 a.m.-11:00 a.m. Break: Marriott Ballroom 7 Foyer
11:00 a.m.-12:00 p.m. Session 10, National Children's Study Panel (NBTS/TS) Marriott Ballroom 6
12:00 p.m. NBTS 2010 Formally Adjourned
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